Intranasal delivery of nerve growth factor attenuates aquaporins-4-induced edema following traumatic brain injury in rats

Q Lv, X Fan, G Xu, Q Liu, L Tian, X Cai, W Sun, X Wang… - Brain research, 2013 - Elsevier
… Here we further studied whether intranasal NGF could attenuate TBI-induced brain edema
and … We found that intranasal administration of NGF (5 μg/d) attenuated the brain edema, as …

Aquaporin 4 in traumatic brain injury: from molecular pathways to therapeutic target

E Dadgostar, S Rahimi, S Nikmanzar, S Nazemi… - Neurochemical …, 2022 - Springer
… -1 α (HIF-1 α) sirtuin 2, NF-κB, Malat1, nerve growth factor … shown to attenuate brain edema,
maintain blood–brain barrier … vascular endothelial growth factor (VEGF) upon brain injury [63]…

[HTML][HTML] Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury

L Manni, G Conti, A Chiaretti… - Neural Regeneration …, 2023 - ncbi.nlm.nih.gov
… with nerve growth factor, intranasally delivered to the brain … , attenuating, among others,
the effects of proNGF on hp-tau. … Continuous infusion of NGF in a rat model of TBI stimulates …

Mildly reduced brain swelling and improved neurological outcome in aquaporin-4 knockout mice following controlled cortical impact brain injury

X Yao, K Uchida, MC Papadopoulos, Z Zador… - Journal of …, 2015 - liebertpub.com
Brain edema following traumatic brain injury (TBI) is associated with considerable morbidity
… In a recent study, intranasal administration of nerve growth factor reduced brain edema after

Intranasal nerve growth factor attenuates tau phosphorylation in brain after traumatic brain injury in rats

Q Lv, W Lan, W Sun, R Ye, X Fan, M Ma, Q Yin… - Journal of the …, 2014 - Elsevier
… On this basis, our team has done a series of research about the effect of NGF on TBI rats. We
found that intranasal delivery of NGF, started at 6 h after TBI, attenuates the brain edema [12…

Intranasal nerve growth factor administration improves cerebral functions in a child with severe traumatic brain injury: a case report

A Chiaretti, G Conti, B Falsini, D Buonsenso, M Crasti… - Brain Injury, 2017 - Taylor & Francis
… The intranasal delivery of NGF to the brain could represent a … Given intranasally in rats with
experimental TBI, NGF has … as attenuating amyloid β42 (Aβ42) deposits and brain oedema

[HTML][HTML] … fibroblast growth factor preserves blood-brain barrier integrity by activating the PI3K-Akt-Rac1 pathway and inhibiting RhoA following traumatic brain injury

F Wu, Z Chen, C Tang, J Zhang, L Cheng… - American journal of …, 2017 - ncbi.nlm.nih.gov
administration attenuated experimental TBI in mice, specifically by preserving endothelial
TJs and AJs, reducing vasogenic brain edema and attenuating neuronal … were intranasally

Acute intranasal treatment with nerve growth factor limits the onset of traumatic brain injury in young rats

L Manni, E Leotta, I Mollica, A Serafino… - British Journal of …, 2023 - Wiley Online Library
Intranasal delivery of nerve growth factor attenuates aquaporins-4-induced edema
following traumatic brainIntranasal administration of nerve growth factor ameliorate beta-amyloid …

… aides in functional recovery following unilateral controlled cortical impact of the forelimb sensorimotor area however intranasal administration of nerve growth factor …

J Young, T Pionk, I Hiatt, K Geeck, JS Smith - Brain Research Bulletin, 2015 - Elsevier
… motor and cognitive function after traumatic brain injury (TBI). … will be more beneficial in
attenuating deficits caused by TBI. … Each rat was weighed and handled for 5 min every day prior …

Nerve growth factor plays a role in the neurotherapeutic effect of a CD45+ pan-hematopoietic subpopulation derived from human umbilical cord blood in a traumatic …

G Gincberg, E Shohami, V Trembovler… - Cytotherapy, 2018 - Elsevier
… that the secondary brain damage that develops after TBI involves neuroinflammatory processes
… their neurotherapeutic effect in TBI mice (Figure 5). p75 NTR , also known as low-affinity …